| 1713 | Birth of Junipero Serra on Majorca, Spain. |
| 1749 | Father Serra is sent to Mexico as a missionary. |
| 1769 | Father Serra is made president of the Baja California missions. |
| 1769 | Sacred Expedition to Alta California. Serra goes along as religious leader. |
| 1769 | July 16. Establishment of San Diego de Alcalá. |
| 1770 | Father Serra sails up the coast to Monterey with Costansó and Fages. |
| 1770 | June 3. Establishment of San Carlos Borromeo de Carmelo (Carmel) at Monterey. |
| 1771 | Father Serra moves San Carlos Borromeo de Carmelo to Carmel to prevent liasons between his female Indian converts and the soldiers at Monterey. |
| 1771 | July 14. Establishment of Mission San Antonio de Padua. |
| 1771 | September 1. Establishment of San Gabriel Arcángel. |
| 1772 - 1773 | Father Serra travels to Mexico City to denounce Fages and ask for more support for his missions. |
| 1772 | September 8. Establishment of San Luis Obispo de Tolosa. The mission becomes a supply center for bear meat. |
| 1774 | San Diego de Alcalá moved to present site. |
| 1775 | Construction of first San Carlos Borromeo de Carmelo Chapel. |
| 1775 | San Gabriel Arcángel is moved to a new site five miles to the east of the original. |
| 1775 | Mission revolt at San Diego de Alcalá. The chapel and outbuildings are burned. |
| 1776 | Mission revolt at San Luis Obispo de Tolosa. The raiders destroy the log buildings by shooting flaming arrows into the thatched roofs. |
| 1776 | June 29. Establishment of San Francisco de Asís (Mission Dolores) by the Arroyo de los Dolores (Our Lady of Sorrows Creek). |
| 1776 | November 1. Establishment of San Juan Capistrano. |
| 1777 | January 12. Establishment of Santa Clara de Asís on the banks of the Guadalupe River. |
| 1777 | Construction of first chapel at San Juan Capistrano. |
| 1779 | Flooding of the Guadalupe River force the relocation of Santa Clara de Asís. |
| 1780 | Reconstruction of San Diego de Alcalá. |
| 1782 - 1791 | Construction of the present chapel at San Francisco de Asís. |
| 1782 | March 31. Establishment of San Buenaventura. It is the last of the missions to be founded by Father Serra. |
| 1784 | Death of Father Serra. He is buried at Carmel. |
| 1784 | Construction of new chapel at Santa Clara de Asís. |
| 1786 | December 4. Establishment of Santa Barbara. |
| 1787 | December 8. First establishment of La Purísima de Concepcíon. |
| 1789 | June 13. Establishment of San Luis Rey de Francia. |
| 1791 | August 28. Establishment of Santa Cruz. |
| 1791 | October 9. First establishment of Nuestra Señora de Soledad. |
| 1791 - 1805 | Construction of San Gabriel Arcángel. |
| 1792 - 1793 | Construction of belfry at San Luis Obispo de Tolosa. |
| 1793 - 1797 | Construction of present sandstone church at San Carlos Borromeo de Carmelo. |
| 1793 | December 14. Raiders from the village of Quiroste, near Point Año Nuevo, attack Mission Santa Cruz, wounding some of the guards and burning the guardhouse and lamb corral. It is the only attack ever made on a northern mission. |
| 1794 | January. Soldiers are dispatched to Santa Cruz from the San Francisco and Monterey presidios. Eight Indians are taken captive. The leaders are shackled and eventually sent to the San Diego Presidio where they die in 1798. |
| 1794 | Construction of chapel at Santa Barbara. |
| 1794 | Original chapel at San Carlos Borromeo de Carmelo replaced by a larger structure. |
| 1795 | Completion of quandrangle at Santa Cruz. |
| 1796 - 1806 | Construction of quandrangle at San Juan Capistrano. |
| 1797 | June 11. Establishment of San José de Guadalupe. |
| 1797 | June 24. Establishment of San Juan Bautista. |
| 1797 | June 25. Establishment of San Miguel Arcángel. |
| 1797 | Completion of chapel at Nuestra Señora de Soledad. It will be washed out several times by floods of the Salinas River. |
| 1797 | Publication of Serra's biography by his friend, Father Francisco Palóu. |
| 1797 | September 8. Establishment of San Fernando Rey de España. |
| 1797 | Establishment of Branciforte Pueblo near Santa Cruz. Tensions between the mission community and the settlers will mount through the years. |
| 1798 | Construction of chapel at San Juan Bautista. |
| 1800 | San Diego de Alcalá destroyed in an earthquake. |
| 1802 | Construction of first chapel at San Luis Rey de Francia. |
| 1803 - 1812 | Construction of present church at San Juan Bautista. |
| 1804 | September 17. Establishment of Santa Inés. |
| 1805 | Enlargement of chapel at Nuestra Señora de Soledad. |
| 1805 - 1809 | Construction of quadrangle at San José de Guadalupe. |
| 1806 | Measles spreads through the northern missions |
| 1806 | Construction of the quadrangle at San Fernando Rey de España. |
| 1809 | Reconstruction of San Buenaventura following a fire. |
| 1810 - 1813 | Construction of quandrangle at ission San Antonio de Padua. |
| 1810 | Establishment of San Gabriel asistencia San Bernardino. |
| 1811 - 1815 | Prosperity allows the construction of the mission quadrangle at San Luis Rey de Francia, the largest of the missions. |
| 1812 | December 8. The Wrightwood Earthquake destroys everything at San Fernando Rey de España except the Convento. |
| 1812 | December 8. Forty Indians are killed in the collapse of the church at San Juan Capistrano. |
| 1812 | December 21. La Purísima de Concepcíon destroyed by earthquake and flood. |
| 1812 | December 21. Santa Inés destroyed in Santa Barbara earthquake. |
| 1812 | December 21. Adobe church at Santa Barbara destroyed by earthquake. |
| 1812 | December 21. San Buenaventura damaged in Santa Barbara earthquake. |
| 1813 | Construction of quadrangle at San Diego de Alcalá. |
| 1813 - 1817 | Reconstruction of Santa Inés. |
| 1814 | Governor Arrillaga buried at Nuestra Señora de Soledad. |
| 1815 - 1818 | Reconstruction of La Purísima de Concepcíon. |
| 1815 - 1833 | Reconstruction of Santa Barbara, a sandstone edifice which will be called the "Jewel of the Missions". |
| 1815 | Establishment of San Luis Rey asistencia San Antonio de Pala. |
| 1816 | Reconstruction of San Buenaventura. |
| 1816 - 1821 | Construction of mission quandrangle at San Miguel Arcángel. The chapel is decorated with trompe l'oeil murals by Estévan Munras and his Indian assistants. |
| 1817 | December 14. Establishment of San Rafael Arcángel. The missions originally serves as a sanitorium for San Francisco de Asís where natives made ill by new diseases brought by settlers and soldiers can recuperate or die. It later serves as a monastery. |
| 1818 | Branciforte settlers sack Santa Cruz during the temporary abandonment of the mission because of a threatened raid by the pirate Bouchard. |
| 1818 | Establishment of San Diego de Alcalá asistencia San Ysabel. |
| 1818 | Thomas Doak decorates the interior of San Juan Bautista. |
| 1818 - 1819 | Construction of new chapel at Santa Clara de Asís. |
| 1823 | July 4. Establishment of San Francisco Solano, last of the missions. |
| 1824 | La Purísima de Concepcíon mission revolt. Santa Inés is also affected. |
| 1825 | Construction of final adobe chapel at Santa Clara de Asís. |
| 1832 | Construction of new chapel at Nuestra Señora de Soledad. |
| 1834 | Secularization of missions. |
| 1836 | Santa Clara de Asís returned to the Catholic Church. |
| 1840 | Construction of parish church at San Francisco Solano. |
| 1842 | Discovery of gold at Placerita Canyon, part of the lands owned by San Fernando Rey de España. |
| 1842 | Mexican President Santa Anna sequesters the Pious Fund, the endowment established for the financing of mission activities in Baja and Alta California. Santa Anna promises to give the interest to the Church. |
| 1848 | Interest payments from the Pious Fund cease with the American invasion of California. |
| 1851 | Transfer of Santa Clara de Asís by the Franciscans to the Jesuits, when it becomes the center of the new University of Santa Clara. |
| 1851 | Mormon settlers use San Bernardino asistencia as a headquarters. |
| 1857 | January 9. Bells at San Gabriel Arcángel thrown to ground by the massive Fort Tejon earthquake. |
| 1862 | San Buenaventura and San Diego de Alcalá returned to the Catholic Church. |
| 1865 | Construction of belfry at San Juan Bautista. |
| 1868 | October 21. San José de Guadalupe destroyed in the Hayward Earthquake. |
| 1870 | San Rafael Arcángel is razed. |
| 1875 - 1876 | An international arbitration commission examines the question of the Pious Fund and rules that the Archdiocese of San Francisco is entitled to half the interest accumulated since 1848. The amount comes to $43,000 in Mexican gold. |
| 1879 - 1930 | Restoration of San Fernando Rey de España. |
| 1884 | Father Casanova erringly restores San Carlos Borromeo de Carmelo. |
| 1890 | After fulfilling its obligations to the Archdiocese of San Francisco up to the year 1869, Mexico refuses to make further interest payments on the Pious Fund. |
| 1893 | Reconstruction of San Luis Rey de Francia, now used as a seminary, begins. |
| 1901 | Renovation of San Miguel Arcángel. |
| 1902 | The Hague Tribunal arranges for Mexico to pay a single lump sum to the Archdiocese of San Francisco as its share of the Pious Fund. ($1,427,682 in Mexican pesos.) |
| 1903 | San Antonio de Pala returned to the Catholic Church. |
| 1904 | Restoration of Santa Inés begins. |
| 1906 | April 18-21. The Great Earthquake and Fire fails to damage San Francisco de Asís. The church, called a fire-trap worthy of demolition, marks the point at which fire fighters stop the further spread of the blaze. The Church decides not to raze the "old firetrap". |
| 1906 | April 18. The Great Earthquake severely damages San Juan Bautista. |
| 1911 - 1913 | Restoration of San Francisco Solano for inclusion in a State Historic Park. |
| 1912 | First production of John McGroarty's The Mission Play in San Gabriel. |
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| 1912 | Annual payments against the Pious Fund debt to the Archdiocese of San Francisco cease with the begining of the Mexican Revolution. |
| 1913 | First publication of Father Francisco Palóu.'s biography of Father Serra in English. |
| 1916 | Construction of basilica at San Francisco de Asís. |
| 1916 | Reconstruction of San José de Guadalupe. |
| 1917 | Restoration of San Francisco de Asís by William Polk. |
| 1918 | April 21. San Juan Capistrano damaged in San Jacinto earthquake. |
| 1924 | Reconstruction of asistencia San Ysabel. |
| 1925 | June 29. Santa Barbara church damaged in earthquake. |
| 1926 | Santa Clara de Asís destroyed by a fire. |
| 1928 | Further renovation of San Miguel Arcángel. |
| 1929 | Reconstruction of Santa Clara de Asís. |
| 1929 | Restoration of San Buenaventura. |
| 1929 | Remodeling of belfry at San Juan Bautista. |
| 1931 | Restoration of San Diego de Alcalá. |
| 1931 | Reconstruction of Santa Cruz. |
| 1932 | Father Serra's birthplace in Majorca, Spain, becomes the property of the City of San Francisco. |
| 1933 | Reconstruction of San Luis Obispo de Tolosa begins. |
| 1935 - 1941 | Reconstruction of La Purísima de Concepcíon |
| 1935 | San Juan Bautista State Historic Park established. |
| 1936 | Proper restoration of San Carlos Borromeo de Carmelo. |
| 1949 | San Rafael Arcángel rebuilt. |
| 1950 | Further reconstruction of San José de Guadalupe. |
| 1950 | Restoration of Santa Barbara facade. |
| 1954 | Reconstruction of Nuestra Señora de Soledad. |
| 1956 - 1958 | Construction of St. Anthony's Seminary at Santa Barbara. |
| 1958 | Alfred Hitchcock's Vertigo features scenes at Missions Dolores and San Juan Bautista. |
| 1963 | Restoration of residence wing at Nuestra Señora de Soledad. |
| 1967 | Mexico's Pious Fund debt is settled with the payment of $719,546 to the Archdioceses of San Francisco and Los Angeles. |
| 1989 | October 18. Santa Cruz is damaged in the Loma Prieta earthquake. |
| 2000 | Insect damage threatens the wood statuary and frame of Mission Dolores. |